This study was approved by the research and ethics committee of our institution. This study was undertaken to quantify the changes in the amplitude and latency of the early cortical SSEP caused by Isoflurane and nitrous oxide when compared to Propofol. Total intravenous anaesthesia using Propofol is an acceptable technique for neurosurgery, but Isoflurane with or without nitrous oxide is still commonly used. Therefore, it is imperative to quantify the changes caused by the anaesthetic agents on SSEP to make it a useful tool to detect nerve damage during surgery. Although, intraoperative changes in SSEP are attributed to surgical trespass, physiological and pharmacological factors can cause temporary changes in their morphology. The latency and amplitude of the early cortical waves is usually monitored during surgery, namely the N20 for the median nerve and P37 for the posterior tibial nerve. Monitoring of Somato Sensory Evoked Potential (SSEP) during surgery is to assess the functional integrity of the sensory pathways in an anaesthetised patient.
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December 2022
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